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knockout crispr library v1 1  (Addgene inc)


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    Structured Review

    Addgene inc knockout crispr library v1 1
    A) Overview of the genome-wide <t>CRISPR</t> knockout screens performed in AM-PDX-derived cell lines. Scheme was produced using Biorender.com. B) Waterfall plot illustrating genes identified as common dependencies in AM007 and AM016 through BAGEL analysis, ranked by their scaled Log Fold Change (sLFC). Selected genes are shown. Dotted lines indicate a significant threshold (0.05 < sLFC < −0.05). C) Comparison of genes identified as essential in acral melanoma (AM, n=5 cell lines) and other tumour types (pan-cancer, n=1010 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). D) Venn diagram showing the overlap of specific dependencies identified in acral, cutaneous, and uveal melanoma, as described in panels C and D. E) Comparison between genes identified as essential in AM (n=5 cell lines) with genes in cutaneous (CM, n=56 cell lines) and uveal melanoma (UM, n=10 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). For panels C and D, only genes identified as more essential in AM are shown. Box plot features: centre line = median; box limits = upper and lower quartiles; whiskers = 1.5x interquartile range; points = outliers.
    Knockout Crispr Library V1 1, supplied by Addgene inc, used in various techniques. Bioz Stars score: 95/100, based on 45 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/knockout crispr library v1 1/product/Addgene inc
    Average 95 stars, based on 45 article reviews
    knockout crispr library v1 1 - by Bioz Stars, 2026-06
    95/100 stars

    Images

    1) Product Images from "Modelling Acral Melanoma in Admixed Brazilians Uncovers Genomic Drivers and Targetable Pathways"

    Article Title: Modelling Acral Melanoma in Admixed Brazilians Uncovers Genomic Drivers and Targetable Pathways

    Journal: medRxiv

    doi: 10.1101/2025.08.08.25332963

    A) Overview of the genome-wide CRISPR knockout screens performed in AM-PDX-derived cell lines. Scheme was produced using Biorender.com. B) Waterfall plot illustrating genes identified as common dependencies in AM007 and AM016 through BAGEL analysis, ranked by their scaled Log Fold Change (sLFC). Selected genes are shown. Dotted lines indicate a significant threshold (0.05 < sLFC < −0.05). C) Comparison of genes identified as essential in acral melanoma (AM, n=5 cell lines) and other tumour types (pan-cancer, n=1010 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). D) Venn diagram showing the overlap of specific dependencies identified in acral, cutaneous, and uveal melanoma, as described in panels C and D. E) Comparison between genes identified as essential in AM (n=5 cell lines) with genes in cutaneous (CM, n=56 cell lines) and uveal melanoma (UM, n=10 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). For panels C and D, only genes identified as more essential in AM are shown. Box plot features: centre line = median; box limits = upper and lower quartiles; whiskers = 1.5x interquartile range; points = outliers.
    Figure Legend Snippet: A) Overview of the genome-wide CRISPR knockout screens performed in AM-PDX-derived cell lines. Scheme was produced using Biorender.com. B) Waterfall plot illustrating genes identified as common dependencies in AM007 and AM016 through BAGEL analysis, ranked by their scaled Log Fold Change (sLFC). Selected genes are shown. Dotted lines indicate a significant threshold (0.05 < sLFC < −0.05). C) Comparison of genes identified as essential in acral melanoma (AM, n=5 cell lines) and other tumour types (pan-cancer, n=1010 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). D) Venn diagram showing the overlap of specific dependencies identified in acral, cutaneous, and uveal melanoma, as described in panels C and D. E) Comparison between genes identified as essential in AM (n=5 cell lines) with genes in cutaneous (CM, n=56 cell lines) and uveal melanoma (UM, n=10 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). For panels C and D, only genes identified as more essential in AM are shown. Box plot features: centre line = median; box limits = upper and lower quartiles; whiskers = 1.5x interquartile range; points = outliers.

    Techniques Used: Genome Wide, CRISPR, Knock-Out, Derivative Assay, Produced, Comparison, MANN-WHITNEY



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    knockout crispr library v1 1  (Addgene inc)
    95
    Addgene inc knockout crispr library v1 1
    A) Overview of the genome-wide <t>CRISPR</t> knockout screens performed in AM-PDX-derived cell lines. Scheme was produced using Biorender.com. B) Waterfall plot illustrating genes identified as common dependencies in AM007 and AM016 through BAGEL analysis, ranked by their scaled Log Fold Change (sLFC). Selected genes are shown. Dotted lines indicate a significant threshold (0.05 < sLFC < −0.05). C) Comparison of genes identified as essential in acral melanoma (AM, n=5 cell lines) and other tumour types (pan-cancer, n=1010 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). D) Venn diagram showing the overlap of specific dependencies identified in acral, cutaneous, and uveal melanoma, as described in panels C and D. E) Comparison between genes identified as essential in AM (n=5 cell lines) with genes in cutaneous (CM, n=56 cell lines) and uveal melanoma (UM, n=10 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). For panels C and D, only genes identified as more essential in AM are shown. Box plot features: centre line = median; box limits = upper and lower quartiles; whiskers = 1.5x interquartile range; points = outliers.
    Knockout Crispr Library V1 1, supplied by Addgene inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/knockout crispr library v1 1/product/Addgene inc
    Average 95 stars, based on 1 article reviews
    knockout crispr library v1 1 - by Bioz Stars, 2026-06
    95/100 stars
    		  Buy from Supplier

    Image Search Results


    A) Overview of the genome-wide CRISPR knockout screens performed in AM-PDX-derived cell lines. Scheme was produced using Biorender.com. B) Waterfall plot illustrating genes identified as common dependencies in AM007 and AM016 through BAGEL analysis, ranked by their scaled Log Fold Change (sLFC). Selected genes are shown. Dotted lines indicate a significant threshold (0.05 < sLFC < −0.05). C) Comparison of genes identified as essential in acral melanoma (AM, n=5 cell lines) and other tumour types (pan-cancer, n=1010 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). D) Venn diagram showing the overlap of specific dependencies identified in acral, cutaneous, and uveal melanoma, as described in panels C and D. E) Comparison between genes identified as essential in AM (n=5 cell lines) with genes in cutaneous (CM, n=56 cell lines) and uveal melanoma (UM, n=10 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). For panels C and D, only genes identified as more essential in AM are shown. Box plot features: centre line = median; box limits = upper and lower quartiles; whiskers = 1.5x interquartile range; points = outliers.

    Journal: medRxiv

    Article Title: Modelling Acral Melanoma in Admixed Brazilians Uncovers Genomic Drivers and Targetable Pathways

    doi: 10.1101/2025.08.08.25332963

    Figure Lengend Snippet: A) Overview of the genome-wide CRISPR knockout screens performed in AM-PDX-derived cell lines. Scheme was produced using Biorender.com. B) Waterfall plot illustrating genes identified as common dependencies in AM007 and AM016 through BAGEL analysis, ranked by their scaled Log Fold Change (sLFC). Selected genes are shown. Dotted lines indicate a significant threshold (0.05 < sLFC < −0.05). C) Comparison of genes identified as essential in acral melanoma (AM, n=5 cell lines) and other tumour types (pan-cancer, n=1010 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). D) Venn diagram showing the overlap of specific dependencies identified in acral, cutaneous, and uveal melanoma, as described in panels C and D. E) Comparison between genes identified as essential in AM (n=5 cell lines) with genes in cutaneous (CM, n=56 cell lines) and uveal melanoma (UM, n=10 cell lines) using DepMap datasets (p < 0.05, Mann-Whitney U test). For panels C and D, only genes identified as more essential in AM are shown. Box plot features: centre line = median; box limits = upper and lower quartiles; whiskers = 1.5x interquartile range; points = outliers.

    Article Snippet: The Human Improved Genome-wide Knockout CRISPR Library v1.1, a gift from Kosuke Yusa (Addgene, 67989), was packaged into lentivirus in HEK293T cells, and BFP expression was used for titration.

    Techniques: Genome Wide, CRISPR, Knock-Out, Derivative Assay, Produced, Comparison, MANN-WHITNEY